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接种疫苗诱导人类的广泛中和抗体前体

David J Leggat¹, Kristen W Cohen², Jordan R Willis^3,4,5

¹Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Science (New York, N.Y.)

|December 1, 2022

概括

这项研究表明,候选艾滋病毒疫苗成功激发免疫系统产生广泛中和抗体 (bnAb) 前体. 这种针对生殖基因的方法是开发有效艾滋病疫苗的关键一步.

科学领域:

免疫学
疫苗学
病毒学

背景情况:

广泛中和抗体 (bnAbs) 提供对艾滋病毒感染的保护,但很难通过接种疫苗诱导.
在bnAb诱导中的主要障碍是罕见的bnAb前体B细胞的有效启动.
正在探索向生殖基因的策略,以克服疫苗开发中的这一局限性.

研究的目的:

评估HIV疫苗候选剂 (eOD-GT8 60mer与AS01B辅助剂) 的安全性和免疫性.
在人类参与者中评估VRC01类bnAb前体的诱导.
建立针对生殖线的疫苗策略的临床概念证明.

主要方法:

进行了一项随机,双盲,安慰剂控制的第一阶段临床试验.
参与者接受了辅助AS01B的eOD- GT8 60mer候选疫苗.
使用流细胞测量和测序来分析B细胞群和抗体前体频率.

主要成果:

这种候选疫苗表现出良好的安全性.
在97%的接种疫苗的患者中诱导了bnAb前体,在IgG B细胞中达到0. 1%的中位频率.
诱导的前体表现出bnAbs的特性,并且在增强后增强了亲和力.

结论:

这项研究提供了针对艾滋病毒的生殖系向疫苗的临床概念证明.
结果支持开发促进方案以实现bnAb诱导.
基因线向策略对抗艾滋病毒和其他病原体具有前景.

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