在 SARS-CoV-2 mRNA 疫苗接种后,抗体反调节免疫记忆
Dennis Schaefer-Babajew1, Zijun Wang1, Frauke Muecksch2
1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Nature
|December 6, 2022
概括
预先存在的高亲和抗体,如单克隆抗体治疗的抗体,可以改变记忆B细胞的发展. 这导致抗体反应效率降低,可能影响疫苗的疗效.
科学领域:
- 免疫学
- 疫苗学
背景情况:
- 抗体可以调节免疫反应,但它们对记忆B细胞发育的影响尚未完全理解.
- 了解已存在的抗体如何影响免疫记忆对于优化疫苗接种策略至关重要.
研究的目的:
- 在mRNA疫苗接种后,研究先前存在的高亲缘性单克隆抗体对记忆B细胞发育的影响.
- 阐明先前存在的抗体形成抗体库和生殖中心选择的机制.
主要方法:
- 在接收抗SARS-CoV-2单克隆抗体后接种mRNA疫苗的个体中分析记忆B细胞群.
- 对抗体亲和度,体位突变和中和能力的评估.
- 在已存在抗体的情况下研究生殖中心形成的小鼠模型.
主要成果:
- 具有先前存在的高亲和抗体的个体表现出主要表达低亲和IgM的记忆B细胞.
- 这些人的抗RBD记忆抗体的百分比很低,
- 在小鼠中的实验表明,先前存在的抗体有利于生殖中心的低亲和性B细胞.
结论:
- 已经存在的高亲和抗体通过降低低亲和克隆的激活值和表位掩盖来偏向生殖中心和B细胞的记忆选择.
- 这种现象可能有助于在强化疫苗接种后观察到的记忆抗体向特异性的变化.
相关概念视频
Immunological Memory
2.9K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
2.9K
Vaccinations
45.1K
Overview
45.1K
Cells of the Adaptive Immune Response
2.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
2.9K
Humoral Immune Responses
73.8K
Overview
73.8K
Cross-reactivity
31.4K
Overview
31.4K
Immune Response Against Viral Pathogens
877
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
877


