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模拟的cPCDH表达调节新皮质的精细组织

Xiaohui Lv1,2,3, Shuo Li1,2,4, Jingwei Li5

  • 1IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China.

Nature
|December 8, 2022
PubMed
概括

聚类原素 (cPCDHs) 调节小鼠新皮层中的神经元排列和连接. 它们的多样化表达模式指导激发神经元的空间组织和突触连接.

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Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
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