一种植物衍生的天然光合作用系统,用于改善细胞合成
Pengfei Chen1,2, Xin Liu1,2, Chenhui Gu1,2
1Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Nature
|December 8, 2022
概括
研究人员开发了一种新型的纳米化光合作用系统,使用在细胞膜 (CM) 中封装的植物衍生的纳米甲基单元 (NTU). 这些CM-NTU有效地恢复细胞内能量水平 (ATP和NADPH),并增强退化的细胞中的合成,为退化的疾病提供了新的治疗策略.
科学领域:
- 生物材料科学
- 细胞生物学
- 纳米技术
背景情况:
- 细胞内代谢对于细胞健康至关重要,但由于ATP (腺三酸盐) 和NADPH (尼古丁胺二核酸盐) 不足而导致的代谢受损与各种病理有关.
- 目前的治疗策略在病态条件下难以有效地恢复最佳细胞内能量水平.
研究的目的:
- 开发一种可控的植物合成系统,
- 证明该系统在恢复细胞能量和改善退化的细胞,特别是肌肉细胞中的有效性.
主要方法:
- 从植物来源开发纳米甲基单位 (NTU).
- 用于针对性输送和跨物种应用,将NTU封装在软细胞膜 (CM) 中.
- 在体外和体内评估CM-NTU吸收,细胞内ATP和NADPH水平的恢复,以及退化的肌肉细胞的功能恢复.
主要成果:
- 通过膜融合,CM- NTU 证明了有效的细胞透,避免了 lysosomal 降解.
- 暴露于光线导致细胞内ATP和NADPH水平显著增加.
- 用CM-NTU治疗改善了代谢,纠正了能量失衡,恢复了细胞代谢,并防止了骨关节炎的进展.
结论:
- 开发的CM-NTU系统代表了可控制的植物衍生光合作用平台,通过独立供应ATP和NADPH来增强细胞合成.
- 这种治疗策略通过恢复细胞能量平衡和改善组织功能来治疗退行性疾病,为生物生物体和复合生物材料的应用提供了洞察力.
相关概念视频
01:32Photosystems
4.9K
Photosystems are multiprotein complexes that form the functional units of photosynthesis in plants, algae, and cyanobacteria. They are found embedded in the membrane of tiny sac-like structures called thylakoids placed inside the chloroplast.
Functioning of Photosystems
Photosystems contain many pigment molecules, such as chlorophylls and carotenoids, arranged in a particular organization across two domains — the antenna complex and the reaction center. The main aim of the pigment...
Functioning of Photosystems
Photosystems contain many pigment molecules, such as chlorophylls and carotenoids, arranged in a particular organization across two domains — the antenna complex and the reaction center. The main aim of the pigment...
4.9K
01:26Oxygenic Photosynthesis
82
Oxygenic photosynthesis is a fundamental process in which light energy is harnessed to drive the oxidation of water, leading to the production of molecular oxygen (O₂), adenosine triphosphate (ATP), and nicotinamide adenine dinucleotide phosphate (NADPH). This process is essential for sustaining aerobic life on Earth and is primarily carried out by cyanobacteria, algae, and plants. The core of oxygenic photosynthesis lies in the thylakoid membranes, where chlorophyll pigments facilitate...
82
00:39What is Photosynthesis?
100.4K
Photosynthesis is a multipart, biochemical process that occurs in plants as well as in some bacteria. It captures carbon dioxide and solar energy to produce glucose. Glucose stores chemical energy in the form of carbohydrates. The overall biochemical formula of photosynthesis is 6 CO2 + 6 H2O + Light energy → C6H12O6 + 6 O2. Photosynthesis releases oxygen into the atmosphere and is largely responsible for maintaining the Earth’s atmospheric oxygen content.
100.4K
01:27Photosystem I
63.9K
Although structurally similar to photosystem II (PSII), photosystem I (PSI) is has a different electron supplier and electron acceptor.
Both these photosystems work in concert. An excited electron from PSII is relayed to PSI via an electron transport chain in the thylakoid membrane of the chloroplast, which is comprised of the carrier molecule plastoquinone, the dual-protein cytochrome complex, and plastocyanin. As electrons move between PSII and PSI, they lose energy and must be re-energized...
Both these photosystems work in concert. An excited electron from PSII is relayed to PSI via an electron transport chain in the thylakoid membrane of the chloroplast, which is comprised of the carrier molecule plastoquinone, the dual-protein cytochrome complex, and plastocyanin. As electrons move between PSII and PSI, they lose energy and must be re-energized...
63.9K
01:08The Anatomy of Chloroplasts
5.3K
Green algae and plants, including green stems and unripe fruit, harbor specialized organelles called chloroplasts to carry out photosynthesis. They coordinate both stages of photosynthesis — the light-dependent reactions and the light-independent reactions. The light-dependent reactions use sunlight to release oxygen and produce chemical energy in the form of ATP and NADPH, and the light-independent reactions capture CO2 and use ATP and NADPH to produce sugar.
Structure of...
Structure of...
5.3K
02:00Photoreceptors and Plant Responses to Light
20.6K
Light plays a significant role in regulating the growth and development of plants. In addition to providing energy for photosynthesis, light provides other important cues to regulate a range of developmental and physiological responses in plants.
20.6K