抗生素巨胺的化学降解启发的总合成

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Aoi Kimishima1, Hiroyasu Ando1, Goh Sennari1

  • 1O̅mura Satoshi Memorial Institute and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Journal of the American Chemical Society
|December 9, 2022
PubMed
概括

研究人员首次完成了复杂的天然产物胺的合成. 通过将化学降解见解与创新的合成策略结合起来,

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Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...
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