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周期性抑制Erk活动驱动着序列性索米特细分

M Fethullah Simsek1, Angad Singh Chandel2,3, Didar Saparov2,4

  • 1Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. muhammed.simsek@cchmc.org.

Nature
|December 14, 2022
PubMed
概括

分段时钟通过调节ppErk梯度来控制身体的分段. 这种梯度,而不是时钟波,对于斑马鱼胚胎形成细分边界至关重要.

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Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
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