一个依赖于微生物组的肠道-大脑通路调节运动的动机
Lenka Dohnalová1,2,3,4, Patrick Lundgren1,2,3, Jamie R E Carty5
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nature
|December 14, 2022
概括
研究人员在小鼠中发现了一条肠-大脑通路, 肠道微生物会产生增加多巴胺的化合物,
科学领域:
- 神经科学
- 微生物学
- 生理学
背景情况:
- 运动对健康有显著的益处, 但对身体活动的动机的神经化学因素尚未完全理解.
- 运动中获得奖励的感觉与大脑神经化学变化有关,
研究的目的:
- 研究肠-大脑轴在运动动机和表现中的作用.
- 找出微生物和神经通路可以增强身体活动和耐力.
主要方法:
- 使用小鼠模型探索肠道微生物对运动能力的影响.
- 研究了内分泌大麻素代谢物,TRPV1感觉神经元和运动期间腹状条纹体中多巴胺信号的作用.
主要成果:
- 发现了肠道与大脑的联系,其中微生物组依赖的内分泌物代谢物刺激TRPV1神经元,在运动期间增加多巴胺水平.
- 已经证明这种途径可以提高小鼠的跑步性能.
- 显示微生物群衰竭,受体抑制或多巴胺阻塞会降低运动能力.
结论:
- 运动的奖励方面是由肠道衍生的感官回路调节的.
- 这种受微生物群影响的肠-大脑通路解释了个体在运动表现上的差异.
- 准这种途径的受体分子可能会提高运动动机.
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