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Updated: Aug 17, 2025

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通过非传统的溶酶体向途径,ATG9A可以防止TNF细胞毒性

Jon Huyghe1,2, Dario Priem1,2, Lisette Van Hove1,2

  • 1VIB Center for Inflammation Research, 9052 Ghent, Belgium.

Science (New York, N.Y.)
|December 15, 2022
PubMed
概括

瘤死亡因子 (TNF) 可以导致细胞死亡,但涉及ATG9A和FIP200的新检查点通过降解细胞毒性复合物来防止这种情况. 这种机制可以防止TNF受体1 (TNFR1) 介导的胚胎死亡和皮肤炎症.

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