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两性聚合物的二次结构与其突出的抗病毒活性之间的直接相关性

Atish Nag¹, Kumarjeet Banerjee², Ranajit Barman¹

¹School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, 2A and 2B Raja S. C. Mullick Road, Kolkata 700032, West Bengal, India.

Journal of the American Chemical Society

|December 16, 2022

概括

一种新的阳离子聚合物F-PU-S通过融合机制抑制病毒进入,对仙台病毒 (SV) 产生强大的抗病毒活性. 它的结构,具有悬挂硫酸盐组和链折叠,对于这种抗病毒作用至关重要.

科学领域:

聚合物化学
材料科学
病毒学

背景情况:

两性细分聚氨可以自组合成复杂的结构.
抗病毒药物通常针对病毒进入机制.
新型抗病毒材料的开发需要了解结构-活性关系.

研究的目的:

研究一种新型两细分聚氨 (F-PU-S) 对仙台病毒 (SV) 的抗病毒活性.
阐明观察到的抗病毒活性背后的机制.
为开发新的抗病毒聚合物建立结构-活性关系.

主要方法:

两类细分聚氨的合成和表征 (F-PU-S,R-PU-S,F-PU-C).
性聚合物的制备.
在体外抗病毒测定对仙台病毒.
涉及聚合物-病毒相互作用的机制研究.

主要成果:

F-PU-S 自组合成具有表面显示硫酸盐组的离子聚合物.
通过抑制病毒进入,F-PU-S对SV表现出显著的抗病毒活性.
机制涉及SV和聚合体的融合,导致更大的颗粒和完整性的损失.
没有链折叠 (R-PU-S) 或具有不同的离子组 (F-PU-C) 的对照聚合物没有抗病毒活性.

结论:

链式折叠和悬挂硫酸盐组对于F-PU-S对抗SV的融合诱导抗病毒活性至关重要.
这项研究为设计有效的抗病毒聚合物提供了结构指南.
聚合体可以作为开发新型抗病毒疗法的平台.

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