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Updated: Aug 16, 2025

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用于铁瘤治疗的含铁蛋白模拟超分子铁输送系统

Shuwei Liu1, Mengsi Zhang2, Hao Jin2

  • 1Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun 130021, P. R. China.

Journal of the American Chemical Society
|December 21, 2022
PubMed
概括

这项研究引入了一种高效的超分子铁输送系统 (SIDS),用于增强瘤治疗. 这种SIDS有效地将铁输送给癌细胞, 增强铁死, 并有望对抗膀癌症.

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Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
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