放射治疗触发的蛋白质溶解以向瘤中的奇米拉前药物激活

Chunrong Yang1, Yuchen Yang1, Yujie Li2

  • 1Department of Chemistry, Center for Bioanalytical Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.

概括

放射治疗触发的PROTAC前药物 (RT-PROTACs) 可以精确控制蛋白质降解,最大限度地降低全身毒性. 这种新的方法使用X射线激活PROTACs进行向治疗.

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