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Updated: Aug 16, 2025

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多重基因编辑可用于真菌天然产品的基因组挖掘的组合表观遗传调节

Fanglong Zhao1, Chunxiao Sun1, Zhiwen Liu1

  • 1Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005, United States.

Journal of the American Chemical Society
|December 21, 2022
PubMed
概括

研究人员开发了一种多重基因编辑 (MBE) 平台,用于高效地操纵真菌基因组. 这种工具通过激活Aspergillus nidulans中的神秘基因集群来发现新型天然产品 (NP).

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相关概念视频

Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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