Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Overview of Somatic Sensory Pathways01:29

Overview of Somatic Sensory Pathways

4.8K
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
4.8K
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

1.1K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
1.1K
Direct Motor Pathways01:11

Direct Motor Pathways

2.2K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
2.2K
Pain01:20

Pain

557
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
557
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

4.2K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
4.2K
Nociception01:44

Nociception

28.3K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
28.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Author Correction: Prefrontal engrams of long-term fear memory perpetuate pain perception.

Nature neuroscience·2026
Same author

Corticothalamic layer 6 controls cortical activity and thalamic firing mode in a bidirectional manner.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same author

Recommendations for the inclusion and study of sex and gender in research.

Nature neuroscience·2025
Same author

Nanoscale Mapping of the Subcellular Glycosylation Landscape.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Neural, psychological, and daily life evidence for a transdiagnostic process of affective dysregulation in depression and chronic widespread pain.

Pain·2025
Same author

A tactile discrimination task to study neuronal dynamics in freely-moving mice.

Nature communications·2025

相关实验视频

Updated: Aug 16, 2025

Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

5.3K

来自主运动皮层的层特异性疼痛缓解途径

Zheng Gan1, Vijayan Gangadharan1, Sheng Liu1

  • 1Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.

Science (New York, N.Y.)
|December 22, 2022
PubMed
概括

主要运动皮层 (M1) 使用不同的途径来控制神经病痛. 一个途径可以减轻疼痛

更多相关视频

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
09:03

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management

Published on: March 28, 2025

575
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

7.8K

相关实验视频

Last Updated: Aug 16, 2025

Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

5.3K
Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
09:03

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management

Published on: March 28, 2025

575
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

7.8K

科学领域:

  • 神经科学
  • 疼痛研究
  • 运动皮层功能

背景情况:

  • 主要运动皮层 (M1) 已知可以控制自发的运动.
  • M1在疼痛调节中的作用已确立,但其特定的神经回路尚不清楚.
  • 神经病的疼痛包括感官和情绪的组成部分.

研究的目的:

  • 阐明源自M1的独特神经通道调节神经病痛.
  • 了解M1如何影响疼痛的感觉和情感方面.
  • 在M1电路内识别潜在的治疗点,以缓解疼痛.

主要方法:

  • 在动物神经病痛模型中使用光遗传和化学遗传技术.
  • 研究了从M1到特定大脑区域的神经投影,包括内核,不确定的区域和水管灰色.
  • 评估了激活或抑制特定M1神经元群体对疼痛行为和感官处理的影响.

主要成果:

  • 发现了一种新型的M1通路,涉及到向中脊丘脑和核投射的6层神经元,可以抑制神经病痛中的负面情绪价值.
  • 发现了一条单独的M1通道, 涉及到5层神经元,
  • 证明这些层特异性途径可以差别调节神经性疼痛的感觉和情绪组成部分.

结论:

  • 主要运动皮层采用不同的,特定层次的电路来独立控制神经病痛的感觉和情绪维度.
  • 向M1层6 - 脊髓 - 胸核通道可能会减轻与疼痛相关的情感痛苦.
  • 针对M1层5- zona incerta- periaqueductal灰色通路可能会减少疼痛过敏.
  • 这些发现为通过调节特定的M1电路开发有针对性的止痛干预提供了新的策略.