接种流感疫苗显示了之前轻度COVID-19的性别二态印记
Rachel Sparks1, William W Lau1, Can Liu1,2
1Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.
Nature
|January 4, 2023
概括
之前的轻度COVID-19感染会改变免疫系统的设定点,影响未来的反应. 由于特定的免疫细胞变化,男性COVID-19康复者表现出增强的疫苗反应.
科学领域:
- 免疫学
- 病毒学
- 系统生物学
背景情况:
- 急性病毒感染可能会导致免疫系统的长期变化.
- 之前感染对免疫平衡和未来反应的影响尚不清楚.
研究的目的:
- 为了比较COVID-19后的个人与对照者的免疫状况和流感疫苗反应.
- 研究之前轻度的COVID-19对免疫反应的两性影响.
主要方法:
- 纵向多模式单细胞分析 (表面蛋白,转录组,V(D) J序列).
- 对流感疫苗接种的基线免疫力和反应的比较评估.
- 对33名COVID-19康复者和40名健康对照者的分析.
主要成果:
- 康复的COVID-19患者显示T细胞活化升高,单细胞的天生的免疫基因表达减少.
- 在接种疫苗后,男性康复者表现出增强的先天性,流感特异性抗体和血细胞反应.
- 观察到性别二态效应,男性康复者表现出明显的单细胞和CD8+ T细胞反应.
结论:
- 轻微的COVID-19建立了新的免疫设定点,影响了未来的抗原无定性免疫反应.
- 之前的病毒感染可能导致免疫功能的长期性变化.
- 免疫反应受到之前的COVID-19感染的调节,特别是在男性中.
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