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Updated: Aug 15, 2025

Selection-dependent and Independent Generation of CRISPR/Cas9-mediated Gene Knockouts in Mammalian Cells
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向RNA释放了CRISPR-Cas12a2的核酶活动

Jack P K Bravo1, Thomson Hallmark2, Bronson Naegle2

  • 1Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.

Nature
|January 4, 2023
PubMed
概括

与CRISPR相关的Cas12a2酶在与目标RNA结合后降解RNA和DNA. 结构研究揭示了其激活途径和赋予人口免疫力的机制.

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