前肢运动阶段在皮层和骨髓之间的结构和功能地图
Wuzhou Yang1, Harsh Kanodia1, Silvia Arber1
1Biozentrum, Department of Cell Biology, University of Basel, 4056 Basel, Switzerland; Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
Cell
|January 7, 2023
概括
这项研究绘制了前皮层 (AC) 和大脑骨髓之间的联系, 揭示了特定皮层区域如何控制前肢运动, 这些发现澄清了用于熟练运动的脑区相互作用.
科学领域:
- 神经科学
- 发动机控制
- 皮层与大脑干的相互作用
背景情况:
- 皮层通过向神经系统的各个区域的投射来控制运动.
- 大脑干的电路对于熟练的前肢运动至关重要,
研究的目的:
- 绘制小鼠前皮层 (AC) 和大脑髓之间的解剖学和功能联系.
- 阐明皮层与神经元控制前肢运动的逻辑.
主要方法:
- 在前皮层和侧髓之间的突触柱的详细解剖绘图.
- 使用沉默技术进行功能性表征,以评估对特定前肢动作的影响 (伸手,操纵).
主要成果:
- 截然不同的前皮层区域在侧髓中形成3D突触柱,在地形上与髓神经元对齐.
- 中间AC (MAC) 向控制触摸的腹部神经元,而侧面AC (LAC) 向处理食物的背部神经元.
- 沉默MAC会影响到达,而沉默LAC会影响食品的处理,这表明功能特异性.
结论:
- 在前皮层和骨髓之间存在精确的地形和功能地图,用于前肢控制.
- 特定的皮质区域映射到不同的神经元群, 调整到特定的动作阶段.
- 皮质神经元利用分离的通道与其他皮质下结构相互作用.
相关概念视频
Motor and Sensory Areas of the Cortex
4.2K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
4.2K
Somatosensory, Motor, and Association Cortex
633
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
633
Somatosensation
37.1K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
37.1K
Direct Motor Pathways
2.2K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
2.2K
Hierarchy of Motor Control
3.0K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
3.0K


