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Updated: Aug 14, 2025

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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在HLA类I缺陷的癌症中,γδ T细胞是免疫疗法的作用因子

Natasja L de Vries1,2, Joris van de Haar3,4,5, Vivien Veninga3,4

  • 1Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Nature
|January 11, 2023
PubMed
概括

具有β2-微球蛋白 (B2M) 不活化的DNA不匹配修复缺陷 (MMR-d) 癌症仍然对免疫检查点阻塞 (ICB) 有反应. 这种反应与 γδ T 细胞的透增加有关,这表明它们在这些癌症的免疫治疗中的作用.

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