寄生虫和宿主之间的Dome1-JAK-STAT信号整合了载体免疫和发育
Vipin S Rana1, Chrysoula Kitsou1, Shraboni Dutta1
1Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
Science (New York, N.Y.)
|January 12, 2023
概括
利用独特的跨物种通信途径,利用哺乳动物干扰素- (IFN-γ) 来激活它们自己的JAK-STAT信号. 这增强了的发育和免疫力,证明了它们对宿主相互作用的进化依赖.
科学领域:
- 进化生物学
- 分子信号
- 寄生虫学
- 免疫学
背景情况:
- 祖先的信号通路对于甲基动物的发育,生理和免疫力至关重要.
- 为了了解宿主和寄生虫之间的相互作用, 种际沟通机制至关重要.
研究的目的:
- 研究涉及Ixodes scapularis受体Dome1的进化跨物种通讯途径.
- 阐明宿主衍生干扰素- (IFN-γ) 在的发育和免疫力中的作用.
- 了解Dome1-JAK-STAT路径对Ixode载体能力的影响.
主要方法:
- 标识和表征Xodes scapularis Dome1受体
- 对Dome1与哺乳动物干扰素- (IFN-γ) 的相互作用进行分析.
- 对的JAK-STAT通路激活的研究.
- 检查Dome1-JAK-STAT通路在肠细胞再生,转化和免疫中的作用.
主要成果:
- 皮虫受体Dome1获得了具有高亲和度的哺乳动物细胞因子受体动机.
- 主体衍生IFN-γ通过Dome1激活了Ixodes的JAK-STAT通路,加速了血粉的获取和发育.
- 该 Dome1-JAK-STAT 途径调节肠道细胞的增殖,转化 (通过刺和 Notch-Delta 网络) 和抗菌成分,影响载体能力.
结论:
- 存在跨物种信号通路,利用宿主IFN-γ来激活它们的内部JAK-STAT通路.
- 这种途径在大多数小虫中存在,对它们的发育,免疫力和转化至关重要.
- Ixodes scapularis表现出对哺乳动物宿主的进化依赖,这种依赖通过跨物种信号传递,影响关节动物的免疫力和发育.
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