在实验性心房动和体外再进入过程中,犬心室在三环周围的马戏团运动
L H Frame1, R L Page, P A Boyden
1Department of Pharmacology, Columbia College of Physicians and Surgeons, New York, NY 10032.
Circulation
|November 1, 1987
概括
这项研究表明,狗的心房是由于三管周围的回流回路引起的. 打断这种通路会阻止心律失常,突出显示治疗的潜在目标.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 心脏节律失常症 心脏节律失常症
背景情况:
- 心房动是一种常见的 supraventricular 高心率.
- 在心房声背后的精确机制,特别是回流电路的作用,需要进一步阐明.
研究的目的:
- 为了研究由狗的右心脏中的Y形病变引起的心房的电生理机制.
- 在心房的狗模型中描述回入路及其特性.
主要方法:
- 记录内心激活序列使用96个双极电极在隔离的透的狗心.
- 诱导和分析心房发作,包括对药物剂 (甲醇,利多卡因) 和过早刺激的反应.
- 利用心房组织的体外超注射来研究三孔周围的重新进入.
- 对心房组织进行组织学检查,以确定解剖基质.
主要成果:
- 在三管口周围的回流回路被确定为诱导心房的机制.
- 途径的手术中断终止了心动减速,并且在没有该途径的隔离心房组织中没有观察到重新进入心脏.
- 慢心周期的长度受到甲胆和利多卡因的影响,并且根据环周和温度而异.
- 传导速度是均的,但在心动减速期间更慢,有证据表明激发能力的恢复不完全.
结论:
- 在这种狗模型中,心房动是由三管周围的宏回入电路介导的.
- 上层膜似乎是解剖学基板,促进了这种重新进入的传播.
- 了解这些机制为管理心房提供了洞察力.
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