与社会地位丧失相关的抑郁状况背后的神经机制
Zhengxiao Fan1, Jiarui Chang2, Yilan Liang2
1Department of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou 311121, China.
Cell
|January 24, 2023
概括
在小鼠中失去社会地位会通过负奖励预测错误触发抑郁行为,这些错误会激活侧面囊 (LHb) 并抑制中间前额叶皮质 (mPFC). 恢复地位可以扭转这些影响.
科学领域:
- 神经科学
- 行为科学
- 精神病学
背景情况:
- 抑郁症的已知危险因素之一是社会流动性下降.
- 连接社会地位下降与抑郁症的基础神经机制尚不清楚.
研究的目的:
- 阐明神经机制将社会地位的丧失与抑郁行为联系起来.
- 研究奖励预测错误和特定大脑区域在这个过程中的作用.
主要方法:
- 通过强迫社会地位的丧失来诱导下降的社会流动性.
- 采用体内光纤测量和单个单位的电生理记录.
- 测量了类似抑郁的行为和神经活动,以应对社会竞争和地位变化.
主要成果:
- 与自然损失不同,强制性社会地位损失导致负奖励预测错误 (RPEs).
- RPE通过侧向下丘脑强烈激活了大脑的反奖励中心,
- LHb激活抑制了中部前额皮质 (mPFC),导致退缩行为增加和类似抑郁症的症状.
- 逆转社会地位成功改善了这些行为和神经变化.
结论:
- 发现一个涉及RPE,LHb和mPFC的核心神经回路,
- 证明社会流动性与心理健康之间的相互作用是由特定的神经元信号通路介导的.
- 强调LHb-mPFC途径是解决社会流动性相关心理障碍的潜在治疗目标.
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