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Updated: Aug 12, 2025

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
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降低亲和力作为一种提高免疫调节抗体激应的策略

Xiaojie Yu1, Christian M Orr2, H T Claude Chan1

  • 1Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton, UK.

Nature
|February 1, 2023
PubMed
概括

通过促进受体聚合,较低的抗体亲和度增强了免疫细胞的激活和抗瘤作用. 这一发现挑战了传统的目标,并为开发强效的免疫调节抗体疗法提供了新的策略.

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