Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

1.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.2K
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K
Nervous System01:21

Nervous System

1.9K
The nervous system coordinates body functions through its complex network of nerve cells, enabling sensation and movement. It is divided into two primary parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and the spinal cord. The brain acts as the body's control center, processing sensory information and coordinating responses. The spinal cord functions as a major signaling pathway for the brain and the rest of the body.
1.9K
What is a Nervous System?01:25

What is a Nervous System?

98.1K
Overview
98.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The tissue-specific regulation of immunobiology by IL-17 signaling.

Science immunology·2026
Same author

An IL-1, IL-17, and IL-22 cytokine circuit controls vulvovaginal candidiasis independently of estrogen.

PLoS pathogens·2026
Same author

An IL-17-DUOX2 axis controls gastrointestinal colonization by Candida albicans.

Nature communications·2026
Same author

Non-canonical IL‑22 receptor signaling remodels the oral mucosal barrier during Candida albicans immunosurveillance.

Nature communications·2026
Same author

Publisher Correction: Colibactin-driven colon cancer requires adhesin-mediated epithelial binding.

Nature·2026
Same author

The RNA binding protein Arid5a is an activator of TNF signaling in rheumatoid arthritis.

JCI insight·2026

相关实验视频

Updated: Aug 11, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

34.7K

当IL-17影响你的神经时

Iliyan D Iliev1, Woan-Yu Lin1, Sarah L Gaffen2

  • 1Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

Cell
|February 3, 2023
PubMed
概括

通过肠道微生物群驱动, 帮助神经受伤后的修复. 在这种再生过程中,外围神经元的IL-17信号传递是关键.

科学领域:

  • 神经免疫学
  • 微生物组研究
  • 外围神经系统的再生

背景情况:

  • 受肠道微生物群的影响,已知会影响中枢神经系统 (CNS) 和动物行为.
  • 对于IL-17在周围神经系统 (PNS) 中的具体作用,至今仍有很大未知之处.

研究的目的:

  • 研究 Th17 细胞和 IL-17 信号在受伤后外围神经再生中的功能.

主要方法:

  • 使用小鼠模型研究开始性特异性Th17细胞在组织损伤后的反应.
  • 在再生过程中分析IL-17信号通路的作用.

主要成果:

  • 证明开始时特定的Th17细胞被招募到外围神经损伤的部位.
  • 这些Th17细胞通过IL-17信号支持局部神经再生.
  • 确定IL-17信号作为一个直接作用于外围神经元的关键介质,以促进修复.

结论:

  • 在受伤后支持周围神经再生方面,体内特定的Th17细胞起着至关重要的作用.
  • 在外围神经元上传递IL-17信号对于调节这种再生反应至关重要,突出显示了微生物群与神经元修复之间的新联系.

更多相关视频

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
07:46

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

3.2K
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
08:02

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

10.0K

相关实验视频

Last Updated: Aug 11, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

34.7K
Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
07:46

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

3.2K
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
08:02

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

10.0K