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Updated: Aug 11, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Published on: February 25, 2022

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罕见遗传性疾病中的异常相分离和核细胞功能障碍

Martin A Mensah1,2,3, Henri Niskanen4, Alexandre P Magalhaes4

  • 1Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Nature
|February 9, 2023
PubMed
概括

内在无序的蛋白质区域中的遗传变异可以破坏像核细胞这样的生物分子凝聚物. 这项研究通过改变蛋白质相分离并导致核细胞功能障碍, 将特定变异与罕见综合征联系起来.

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Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo10:10

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