相关实验视频

Updated: Aug 11, 2025

In ovo Electroporation of miRNA-based Plasmids in the Developing Neural Tube and Assessment of Phenotypes by DiI Injection in Open-book Preparations
12:41

In ovo Electroporation of miRNA-based Plasmids in the Developing Neural Tube and Assessment of Phenotypes by DiI Injection in Open-book Preparations

Published on: October 16, 2012

16.6K

通过网络推断和基因扰动剖析细胞身份

Kenji Kamimoto1,2,3, Blerta Stringa1,3, Christy M Hoffmann1,2,3

  • 1Department of Developmental Biology, Washington University School of Medicine in St Louis, St Louis, MO, USA.

Nature
|February 9, 2023
PubMed
概括

这项研究介绍了一种机器学习工具CellOracle,该工具模拟基因调节网络以预测细胞身份的变化. 细胞Oracle准确地模拟发育中的转录因子扰动,并识别出新型调节者.

更多相关视频

The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy12:15

The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy

Published on: October 3, 2017

13.5K
Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights08:23

Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights

Published on: June 28, 2024

879

相关概念视频

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
14.1K