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Updated: Aug 10, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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基于2-乙烯基甲,向素的蛋白激酶和非激酶的不可逆共价抑制剂

Peng Chen1, Guanghui Tang2, Chengjun Zhu3

  • 1School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.

Journal of the American Chemical Society
|February 12, 2023
PubMed
概括

这项研究引入了一种基于2-乙烯基 (EBA) 的新策略,用于制造选择性,细胞活性素向的不可逆转共价抑制剂. 该方法成功生成了ABL激酶,EGFR和Mcl-1的强效抑制剂,证明了其广泛适用性.

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