乙型肝炎
Wen-Juei Jeng1, George V Papatheodoridis2, Anna S F Lok3
1Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Lancet (London, England)
|February 12, 2023
概括
乙型肝炎病毒 (HBV) 感染全球数以百万计的人. 虽然目前的治疗方法可以控制病毒,
科学领域:
- 肝病学
- 病毒学
- 公共卫生
背景情况:
- 乙型肝炎病毒 (HBV) 感染是全球严重的健康问题,每年造成数以百万计的感染和死亡.
- 准确的诊断依赖于血清标志物,如HBsAg和IgM抗HBc,HBVDNA评估复制和肝病活动.
- 尽管有效的疫苗和当前的疗法可以预防严重的后果,但它们很少实现病毒根除或HBsAg清除.
研究的目的:
- 审查目前的乙型肝炎诊断,治疗和预防策略.
- 突出现有治疗方法的局限性和需要新的方法.
- 讨论实现世界卫生组织消除乙型肝炎病毒目标的进展和未来方向.
主要方法:
- 对包括血清检测和HBVDNA量化在内的诊断方法的审查.
- 分析当前的治疗方案,如化干扰素和核胺类同类.
- 在临床开发中探索新兴抗病毒和免疫调节疗法.
主要成果:
- 目前的诊断和治疗策略可以控制HBV感染并预防并发症,但无法治愈.
- 对于成年人来说,有了新的免疫性提高的疫苗,婴儿普遍接种疫苗仍然是预防的关键.
- 有望的新疗法正在开发中,目的是实现功能治疗 (HBsAg清除).
结论:
- 为了实现世界卫生组织2030年消除乙型肝炎病毒的目标,需要加强疫苗接种,查和与护理联系.
- 开发治愈疗法对于病毒根除和功能治愈至关重要.
- 解决与HBV感染相关的耻辱也是有效的公共卫生干预的关键.
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