低密度脂蛋白胆固醇水平与长期心血管和安全结果之间的关联:FOURIER-OLE的分析
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在PubMed上查看摘要
概括
此摘要是机器生成的。达到低密度脂蛋白胆固醇 (LDL- C) 水平低于20 mg/ dL,可显著降低动脉样性心血管疾病患者的心血管风险. 这项扩展研究没有发现持续降低LDL- C的安全问题增加.
科学领域
- 心脏病学
- 临床研究
- 药理学
背景情况
- 低密度脂蛋白胆固醇 (LDL-C) 是动脉样硬化心血管疾病 (ASCVD) 的一个关键风险因素.
- 在ASCVD患者中,最佳的长期LDL- C有效性和安全性仍未确定.
研究的目的
- 研究达成的LDL-C水平与心血管结果之间的长期关系.
- 在已确定的ASCVD患者中评估非常低的LDL- C水平的安全性.
主要方法
- 对FOURIER试验及其开放式扩展试验 (FOURIER-OLE) 的数据进行分析.
- 检查了达成的LDL- C水平 (< 20, 20 < 40, 40 < 55, 55 < 70, ≥70 mg/ dL) 以及随后的心血管和安全结果.
- 使用多变量建模来调整基线因素,并对整个队列进行敏感性分析.
主要成果
- 随着较低的LDL- C水平,观察到心血管事件的单调下降,降至< 20 mg/ dL (调整后P< 0. 0001).
- 没有统计学意义上的重大安全结果 (例如癌症,中风,糖尿病,肌肉事件) 的风险增加与较低的LDL- C水平相关.
- 结果在整个FOURIER和FOURIER-OLE群体中一致,随访时间长达8. 6年.
结论
- 在ASCVD患者中,持续达到非常低的LDL- C水平 (< 20 mg/ dL) 与心血管风险降低有关.
- 没有发现长期非常低的LDL- C水平存在重大安全问题.
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