Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

964
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
964
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

712
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
712
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

604
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
604
Antigen Processing Pathways01:31

Antigen Processing Pathways

1.2K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
1.2K
Antigen Presenting Cells01:22

Antigen Presenting Cells

2.0K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
2.0K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

69.6K
Overview
69.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A transient epithelial plasticity state defines the developmental window for uterine gland specification.

bioRxiv : the preprint server for biology·2026
Same author

Spatiotemporal cellular map of the developing human reproductive tract.

Nature·2025
Same author

A novel paradigm for single-cell annotation in stem cell research.

Stem cell reports·2025
Same author

Protocol for a human placental explant model to study acute responses to pathogens.

STAR protocols·2025
Same author

Atlas of amnion development during the first trimester of human pregnancy.

Nature cell biology·2025
Same author

How machine learning can help us understand what we have grown in the dish.

Nature reviews. Molecular cell biology·2025
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
查看所有相关文章

相关实验视频

Updated: Aug 9, 2025

Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers
09:15

Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers

Published on: July 19, 2024

1.1K

解码外来抗原的耐受性

Roser Vento-Tormo1,2

  • 1Wellcome Sanger Institute, Cambridge, UK.

Science (New York, N.Y.)
|February 16, 2023
PubMed
概括
此摘要是机器生成的。

人类耐受性环境的细胞地图为新的免疫疗法铺平了道路. 这些免疫抑制组织的详细地图对于开发先进疗法至关重要.

更多相关视频

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

10.8K
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

14.4K

相关实验视频

Last Updated: Aug 9, 2025

Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers
09:15

Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers

Published on: July 19, 2024

1.1K
Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

10.8K
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

14.4K

科学领域:

  • 免疫学
  • 细胞生物学
  • 医学研究

背景情况:

  • 了解免疫耐受性对于治疗自身免疫性疾病和实现器官移植至关重要.
  • 目前对人类耐药性环境的了解有限,阻碍了向免疫疗法的开发.

研究的目的:

  • 创建人类耐受性环境的综合细胞地图.
  • 用这些图谱来设计新型和变革性的免疫疗法.

主要方法:

  • 单细胞RNA测序以分析细胞组成和状态.
  • 空间转录学以了解组织架构和细胞间的相互作用.
  • 生物信息分析将多种数据整合起来,并确定关键的监管途径.

主要成果:

  • 在人类耐受性环境中的细胞参与者的详细描述.
  • 与免疫抑制相关的新细胞子集和分子特征的识别.
  • 保持免疫平衡的细胞相互作用的映射.

结论:

  • 细胞地图提供了人类免疫耐受性的前所未有的洞察力.
  • 这些地图书是指导下一代免疫疗法的基础资源.
  • 针对已识别的途径和细胞类型有望进行临床转化.