鱼虫病毒变得非常基本
1Department of Infectious Disease, King's College London, London, UK.
Cell
|February 21, 2023
概括
活哺乳动物的贩运带来了动物传染病毒的风险. 一项新的研究在贩运的鱼中发现了一种与MERS相关的冠状病毒,它表现出广泛的哺乳动物适应性和一种新型的furin裂部位.
科学领域:
- 病毒学
- 动物传染病
- 野生动物贸易
背景情况:
- 活哺乳动物的贩运是动物传播病毒的重要途径.
- 全球人口最多的哺乳动物 - - 松鼠,此前与SARS-CoV-2相关的冠状病毒有联系.
研究的目的:
- 调查贩运的松鼠中冠状病毒的存在和特征.
- 评估已识别的冠状病毒的动物感染潜力.
主要方法:
- 病毒遗传材料的基因分析.
- 病毒蛋白结构和功能的分析.
主要成果:
- 在贩运的鱼中发现与MERS相关的冠状病毒.
- 已发现的冠状病毒在各种哺乳动物中表现出广泛的热带性.
- 在与MERS相关的冠状病毒的Spike蛋白中检测到一种新获得的furin分裂部位.
结论:
- 贩运的松鼠携带具有显著动物感染潜力的MERS相关冠状病毒.
- 素分裂部位的存在表明病毒进入和传播能力有所增强.
- 这一发现突显了加强野生动物贸易监督和监管的迫切需要, 以减轻流行病风险.
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