相关实验视频

Updated: Aug 9, 2025

A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

Published on: June 16, 2013

由VEGF分泌驱动的癌细胞选择性膜受体集群用于活体治疗

Shiyi Bi¹, Wei Chen², Yanyun Fang¹

¹State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Journal of the American Chemical Society

|February 23, 2023

概括

这项研究引入了一种用于选择性瘤细胞的新型DNA纳米链策略. 这种方法精确地聚合了癌细胞上的细胞受体, 诱导了对健康细胞的影响最小的细胞灭亡.

科学领域:

生物技术
纳米医学
癌症生物学

背景情况:

细胞膜受体聚合对于细胞信号传递至关重要,并具有治疗应用.
目前用于癌症治疗的受体聚类方法缺乏选择性,影响正常细胞.
针对拉吉细胞的CD20是选择性癌症治疗的挑战.

研究的目的:

为拉吉癌细胞开发一种选择性受体聚类策略.
设计一种对拉吉细胞分泌物有反应的DNA纳米链,
研究新策略的疗效和选择性.

主要方法:

使用可收回的DNA纳米链设计了一种选择性处理受体集群 (SMARC) 策略.
在Raji细胞的CD20受体上定DNA纳米链.
使用拉吉细胞分泌的血管内皮生长因子 (VEGF) 和具有DNA循环反应的VEGF放大器来触发纳米链收缩和CD20聚合.

主要成果:

通过SMARC策略,在Raji细胞上实现了CD20的选择性聚类.
在对正常B细胞的最小干扰下,证明了Raji细胞的有效亡.
在临床前模型中显示出有前途的体内疗效.

结论:

通过操纵受体聚类,SMARC战略提供了精确和选择性的癌症治疗方法.
这种方法为向癌症治疗提供了一个有前途的工具,
这项研究强调了DNA纳米结构在开发先进的癌症疗法方面的潜力.

更多相关视频

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model

Published on: February 3, 2021

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...