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通过细菌cGAS类似的结合增强了抗菌体防御

Justin M Jenson1,2, Tuo Li1,2,3, Fenghe Du1,2,3

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Nature
|February 27, 2023
PubMed
概括

细菌使用类似于泛素的机制来控制对菌体感染的cGAS酶活性. 这涉及蛋白质结合以促进循环GMP-AMP (cGAMP) 的产生,然后通过隔离cGAMP来抵消菌体.

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