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针对新抗原的CD8+ T细胞反应与PD-1阻断疗法

Cristina Puig-Saus1,2,3,4, Barbara Sennino5, Songming Peng5

  • 1Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA. cpuigsaus@mednet.ucla.edu.

Nature
|March 8, 2023
PubMed
概括

在黑色素瘤中,有效的抗编程死亡受体-1 (PD-1) 免疫疗法与针对特定突变的多克隆CD8+T细胞有关. 这些新抗原特异性T细胞随着时间的推移在血液和瘤中经常被检测到.

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