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Updated: Aug 7, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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通过第三个细胞内循环进行GPCR信号的自调节

Fredrik Sadler1,2, Ning Ma3,4, Michael Ritt2

  • 1Biochemistry, Molecular Biology and Biophysics Graduate Program, University of Minnesota, Minneapolis, MN, USA.

Nature
|March 8, 2023
PubMed
概括

G蛋白结合受体 (GPCR) 的第三个细胞内环 (ICL3) 通过控制G蛋白结合来调节信号传递. 这种循环作为一个全位,影响整个GPCR超级家族的受体活性和特异性.

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