Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Tracking Gene Expression of Single Mitochondria in Live Neurons Using Nanotweezers.

Journal of the American Chemical Society·2026
Same author

Bio-Inspired and Protein-Based Elastomeric Materials.

Polymer science & technology (Washington, D.C.)·2026
Same author

Super-Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

The mechanochemical activation of a pyrimidine dimer.

Chemical science·2026
Same author

Two-Dimensional Polymers as Modular Metal-Free Solid-State Catalysts for Efficient Sono-Piezo-Photocatalytic Hydrogen Peroxide Production.

Angewandte Chemie (International ed. in English)·2026
Same author

Precise Mechanochemical Scission of DNA Guided by Secondary Structures.

Journal of the American Chemical Society·2026

相关实验视频

Updated: Aug 7, 2025

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

11.8K

使用超充电多分子载体的纳米孔检测

Xiaoyi Wang1, Tina-Marie Thomas2,3, Ren Ren1,4

  • 1Department of Chemistry, Imperial College London, Molecular Science Research Hub, London W12 0BZ, U.K.

Journal of the American Chemical Society
|March 10, 2023
PubMed
概括
此摘要是机器生成的。

通过对蛋白质进行基因融合的超充电非结构性多 (SUPs) 可实现控制的纳米孔传感. 这种方法增强了单分子蛋白质的检测和分化,克服了目前生物分析的局限性.

更多相关视频

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example
08:42

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Published on: October 26, 2016

12.4K
Monitoring Protein Adsorption with Solid-state Nanopores
08:51

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

13.6K

相关实验视频

Last Updated: Aug 7, 2025

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

11.8K
Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example
08:42

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Published on: October 26, 2016

12.4K
Monitoring Protein Adsorption with Solid-state Nanopores
08:51

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

13.6K

科学领域:

  • 生物物理
  • 分子生物学
  • 分析化学

背景情况:

  • 对蛋白质的单分子分析对于理解生物过程和疾病至关重要,特别是对于低丰度的点.
  • 纳米孔传感提供单一蛋白质的无标签检测,并可用于生物标志物查和药物发现.
  • 目前的纳米孔感应在控制蛋白质转移和与读数相关的结构/功能方面面临挑战.

研究的目的:

  • 开发一种使用纳米孔感应增强蛋白质控制和检测的方法.
  • 研究将基因合超载无结构聚 (SUP) 作为蛋白质的分子载体的使用.
  • 克服目前单分子蛋白质分析的空间时间限制.

主要方法:

  • 基因融合超级无结构聚 (SUP) 与标蛋白.
  • 通过静电相互作用通过纳米孔调节蛋白质转移.
  • 分析纳米孔电流信号以根据大小和形状区分蛋白质.

主要成果:

  • SUP显著减缓通过纳米孔的蛋白质转移.
  • 纳米孔电流中的特征子峰允许单个蛋白质的分化.
  • 在单个分子水平上控制分子运输的可行方法.

结论:

  • 基因工程 SUP 作为有效的分子载体,用于增强蛋白质的纳米孔检测.
  • 这种方法有助于单分子蛋白的分化和相互作用研究.
  • SUP为克服纳米孔探测在生物应用中的局限性提供了一个有希望的策略.