相关实验视频

Updated: Aug 6, 2025

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

饮食中的甜味剂糖是T细胞介导反应的负调节剂

Fabio Zani¹, Julianna Blagih^2,3, Tim Gruber⁴

¹p53 and Metabolism Laboratory, The Francis Crick Institute, London, UK. fabio.zani@crick.ac.uk.

|March 16, 2023

概括

通过影响T细胞功能,高摄入的人造甜味剂糖可抑制小鼠的免疫反应. 这一发现表明自身免疫性疾病的潜在治疗应用.

科学领域:

免疫学
毒理学
食品科学

背景情况:

人造甜味剂,如糖,被广泛用作糖的替代品.
人工甜味剂的长期安全和健康影响令人担忧.

研究的目的:

研究高剂量糖摄入的免疫调节作用.
探索糖糖对T细胞反应的影响机制.

主要方法:

给小鼠使用高剂量的糖.
分析T细胞的增殖,分化和功能.
对T细胞受体信号和膜性质的评估.
在癌症,感染和自身免疫模型中评估免疫反应.

主要成果:

糖的摄入限制了T细胞的增殖和分化.
糖改变了T细胞膜的顺序,降低了T细胞受体信号的效率.
在癌症和感染模型中,食用糖的小鼠表现出CD8+ T细胞反应的减少.
在自身免疫模型中观察到T细胞功能下降.

结论:

高糖摄入量可以抑制T细胞介导的免疫反应.
糖的免疫调节作用需要进一步研究其在自身免疫性疾病中的潜在治疗用途.

更多相关视频

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

相关概念视频

The Physiology of Taste

The Physiology of Taste

The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Cell-mediated Immune Responses

Cell-mediated Immune Responses