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Updated: Aug 6, 2025

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay

Published on: February 28, 2025

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作为分子剂药物发现方法的14-3-3/ERRγ蛋白-蛋白相互作用的可逆双共价分子锁定

Bente A Somsen1, Rick J C Schellekens1, Carlo J A Verhoef1

  • 1Laboratory of Chemical Biology, Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

Journal of the American Chemical Society
|March 17, 2023
PubMed
概括

研究人员开发了"分子锁",即双共价分子,通过可逆交叉连接蛋白质来稳定蛋白质与蛋白质的相互作用. 这种方法可以快速生成用于分子剂药物发现和生物物理研究的工具化合物.

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