慢性淋巴细胞白血病的诊断和治疗:一个综述
1Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.
JAMA
|March 21, 2023
概括
慢性淋巴细胞白血病 (CLL) 在美国影响超过20万人. 新型向药物如布鲁顿氨酸激酶 (BTK) 和B细胞白血病/淋巴瘤2 (BCL2) 抑制剂为需要治疗的患者提供了有效的治疗选择.
科学领域:
- 血液学
- 癌症学
- 免疫学
背景情况:
- 慢性淋巴细胞白血病 (CLL) 是一种流行的B细胞恶性瘤,在美国影响超过20万人,每年约有4410人死亡.
- 这种疾病的特征是免疫功能受损,增加感染和并发症的风险.
- 诊断时的中位数年龄为70岁,大多数患者有并发症;许多患者在诊断时无症状,三分之一从未需要治疗.
结论:
- 有效的向治疗显著改善了CLL患者的治疗结果.
- 基于患者特征和疾病进展的个性化方法.
- 异构造血细胞移植仍然是CLL的潜在治疗方法,特别是在向药物失效后.
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