严重感染和心血管疾病风险:多队列研究
Pyry N Sipilä1,2, Joni V Lindbohm1,3, G David Batty3
1Departments of Public Health (P.N.S., J.V.L., S.T.N., J.P., M.K.).
Circulation
|March 27, 2023
概括
严重的感染显著增加了短期和长期重大心血管事件的风险. 这一关联凸显了预防心脏病和中风的重要作用.
科学领域:
- 心脏病学
- 传染性疾病
- 流行病学
背景情况:
- 各种传染病与心血管疾病 (CVD) 风险之间的联系尚未完全理解.
- 在重症感染后量化短期和长期心血管疾病风险对于公共健康至关重要.
- 估计感染导致的心脏病的比例可以为预防策略提供信息.
研究的目的:
- 量化严重感染后发生重大心血管事件的短期和长期风险.
- 估计与严重感染有关的心血管事件的占人口比例.
主要方法:
- 使用英国生物库数据 (331,683名参与者) 和复制芬兰队列数据 (271,329名参与者) 的发现.
- 在确诊感染后评估发生的重大心血管事件 (心肌梗塞,心脏死亡,中风).
- 计算的调整危险比率 (HRs) 和可归因于人群的分数,控制心血管风险因素.
主要成果:
- 无论感染类型如何,因感染而住院的风险都会增加.
- 感染后的第一个月风险最高 (HR: 7. 87英国生物库, 7. 64芬兰),但长期仍然较高 (HR: 1. 47英国生物库, 1. 41芬兰).
- 严重的感染占4. 4% (英国生物库) 和6. 1% (芬兰) 的可归因心血管事件.
结论:
- 在医院治疗的感染显著增加了重大心血管事件的直接和长期风险.
- 这些发现强调了严重感染对心血管的影响.
- 在长期风险观察中不能完全排除残留混.
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