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Updated: Aug 5, 2025

Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes
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Published on: January 30, 2019

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用于调节哺乳动物细胞和动物中的RNA功能的小分子Aptamer

Keisuke Fukunaga1, V Dhamodharan1, Nao Miyahira1

  • 1Nucleic Acid Chemistry and Engineering Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa 904 0495, Japan.

Journal of the American Chemical Society
|March 30, 2023
PubMed
概括

研究人员使用新型RNA体开发了用于哺乳动物细胞基因调节的合成体开关. 这些核突开关在低度下对ASP7967等小分子作出反应,使细胞培养和体内基因表达得到精确控制.

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