美国儿童患有急性严重肝炎的2型腺相关病毒
Venice Servellita1, Alicia Sotomayor Gonzalez1, Daryl M Lamson2
1Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Nature
|March 30, 2023
概括
严重的儿科肝炎病例与2型腺相关病毒 (AAV2) 联合感染有关. 这项研究在93%的肝炎病例中发现了AAV2,这表明它与辅助病毒一起在严重疾病中起作用.
科学领域:
- 病毒学
- 儿童传染病
- 分子生物学
背景情况:
- 据报道,从2022年开始,在未知来源的儿童中发生严重急性肝炎的全球爆发.
- 人类腺病毒 (HAdV) 之前在一些受影响的儿童中被检测到,但它们的致病作用仍然不确定.
研究的目的:
- 研究儿童严重急性肝炎的病毒病因.
- 确定腺相关病毒2型 (AAV2) 和其他病毒与儿童肝炎病例的相关性.
主要方法:
- 对16名HAdV阳性肝炎儿童和113名对照个体的样本进行分析.
- 使用PCR测试,基于病毒丰富的测序和无定性基因组测序.
- 病毒检测率的比较,包括AAV2,HAdV,爱斯坦-巴尔病毒,人类疹病毒6和肠道病毒A71,病例和对照.
主要成果:
- 在93%的肝炎病例中检测到2型腺相关病毒 (AAV2) 序列,明显高于对照组 (3, 5%).
- 与肝炎病例相比,HAdV型41在胃肠炎的对照群中很常见,但与AAV2同时感染的情况较少.
- 与疹病毒 (埃普斯坦- 巴尔病毒,人类疹病毒6) 和肠道病毒A71的同时感染在肝炎病例中占比高 (85. 7%).
结论:
- 这些发现强烈表明AAV2在重症儿科肝炎的发病过程中起着重要作用.
- 疾病的严重程度似乎与涉及AAV2和辅助病毒 (如疹病毒) 的同时感染有关.
- 需要进一步研究以阐明儿童AAV2相关性肝炎的确切机制.
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