Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

4.8K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Knee Osteoarthritis on MRI in Symptomatic Young Adults After ACL Reconstruction From the SUPER-Knee Trial: Feature Prevalence and Association With Early-Stage Clinical Osteoarthritis Criteria.

Orthopaedic journal of sports medicine·2026
Same author

CLPTM1L modulates membrane lipid rafts to promote tumor EGFR signaling.

Life metabolism·2026
Same author

Applications of transcranial focused ultrasound for primary brain tumors.

Neuro-oncology advances·2026
Same author

ERO1a fosters glioblastoma aggressiveness and metabolic flexibility by regulating mitochondria-associated membrane dynamics.

Nature cell biology·2026
Same author

High-depth whole genome sequencing of premalignant breast lesions reveals rearrangement hotspots and personalized management opportunities.

Nature communications·2026
Same author

Fast and accurate resolution of ecDNA sequence using Cycle-Extractor.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Aug 4, 2025

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
15:53

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Published on: August 21, 2013

15.0K

一种细胞类型选择性YM155前药物向受体相互作用蛋白激酶2诱导脑癌细胞死亡

Thomas J West1, Junfeng Bi2, Francisco Martínez-Peña1

  • 1Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.

Journal of the American Chemical Society
|April 5, 2023
PubMed
概括

一种新型前药,aYM155,有效地向质母细胞,并增强大脑透. 这种前药在癌细胞内选择性地激活,通过向生存蛋白和受体相互作用蛋白激酶2 (RIPK2) 来抑制瘤生长.

更多相关视频

Author Spotlight: Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures
04:01

Author Spotlight: Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures

Published on: June 23, 2023

1.8K
Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

11.1K

相关实验视频

Last Updated: Aug 4, 2025

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
15:53

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Published on: August 21, 2013

15.0K
Author Spotlight: Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures
04:01

Author Spotlight: Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures

Published on: June 23, 2023

1.8K
Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

11.1K

科学领域:

  • 癌症学
  • 药理学
  • 神经科学

背景情况:

  • 质母细胞瘤 (GBM) 是一种具有有限治疗选择的侵袭性脑癌.
  • YM155是一种强效的抗癌药物,抑制了生存,但缺乏细胞类型选择性,导致耐受性问题.
  • 开发针对性治疗GBM仍然是一个关键的未满足需求.

研究的目的:

  • 为改善质母细胞瘤治疗而设计和合成YM155的前药物.
  • 评估aYM155的细胞杀伤活性,选择性和大脑透.
  • 阐明YM155及其前的作用机制.

主要方法:

  • 合成和YM155前药物 aYM155 的特征.
  • 对来自患者的GBM细胞和EGFR增强细胞系的细胞杀死活性进行了体外评估.
  • 质谱分析前药激活率和大脑透率 (大脑与血的比率).
  • 在体内评估aYM155在骨头内GBM异种移植模型中的疗效.

主要成果:

  • aYM155对GBM癌症干细胞和EGFR增强细胞系表现出强烈的细胞杀伤活性.
  • 预制剂的激活取决于细胞类型,增强了转化细胞的选择性.
  • 与原始药物YM155相比,aYM155表现出较好的脑传输.
  • 通过RIPK2相互作用,YM155的抗癌作用与生存抑制和亡诱导有关.
  • aYM155 在体内显著抑制了GBM瘤的生长,具有选择性的药理动力学效应.

结论:

  • aYM155代表了质母细胞瘤的一种有前途的药物策略,提供了更强的选择性和大脑透.
  • 前药的疗效由细胞类型的选择性激活和生存/ RIPK2通路的向介导.
  • 对aYM155在治疗GBM中的潜在临床应用有必要进行进一步的研究.