概括
孕妇在怀孕早期使用性激素可能会增加婴儿食道缩的风险. 然而,与非避孕性性激素暴露相关的绝对风险仍然很低.
科学领域:
- 产科和妇科 产科和妇科
- 儿科手术 儿科手术
- 医学遗传学 医学遗传学
背景情况:
- 在怀孕初期,母亲使用外源性激素被怀疑与先天性形有关.
- 现有的研究表明存在潜在的联系,需要进一步研究特定的激素类型和形.
研究的目的:
- 调查第一季度性激素暴露与婴儿先天性形之间的关联.
- 识别特定的激素类型及其与特定形的相关性.
主要方法:
- 进行了一项病例控制研究,涉及1,091名被诊断患有唐氏综合征或11种主要形之一的婴儿.
- 患有其他发育不良的婴儿作为每个特定发育不良类别的对照.
- 分析的重点是母亲在头三个月内暴露于各种性激素.
主要成果:
- 在食道缩和暴露于任何性激素 (OR,2.84),孕激素 (OR,2.87),未指定的性激素 (OR,2.99) 和激素妊娠测试 (OR,2.81) 之间观察到一个统计学上显著的关联.
- 对于这些关联,没有发现任何混变量.
- 在任何形和口服避孕药暴露之间没有发现显著的关联.
结论:
- 非避孕性激素暴露,特别是孕激素和激素怀孕测试,与食道缩的风险增加有关.
- 尽管观察到这种关联,但这种暴露导致食道缩的绝对风险很低,估计约为每10,000名活产婴儿中有6名.
- 在怀孕第一季度使用口服避孕药并没有与所研究的发育不良有显著的关联.
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