小滑板基因组和翼状的进化出现
Ferdinand Marlétaz1,2, Elisa de la Calle-Mustienes3, Rafael D Acemel3,4
1Centre for Life's Origin and Evolution, Department of Genetics, Evolution and Environment, University College London, London, UK. ferdinand.marletaz@gmail.com.
Nature
|April 12, 2023
概括
研究人员探索了滑板发育的遗传基础. 他们发现影响平面细胞极性通路的基因组重组是它们独特的翅膀状胸进化的关键.
科学领域:
- 进化生物学
- 基因组学
- 发育生物学
背景情况:
- 滑板 (batoids) 具有独特的,扩大的胸,可以在地底运动.
- 驱动这种独特的形态的分子机制尚不清楚.
研究的目的:
- 研究滑板胸进化的基因组和监管基础.
- 鉴定导致滑冰机翅膀形成的遗传因素.
主要方法:
- 开发了小滑板 (Leucoraja erinacea) 作为具有高质量的基因组序列的模型生物.
- 进行了比较基因组学,基因表达分析,染色质占用和3D基因组构造研究.
- 使用平面细胞极性通路的功能抑制和斑马鱼报告测试.
主要成果:
- 确定了影响平面细胞极性通路基因的基因结构重组.
- 证明平面细胞极性信号对于前尺寸至关重要.
- 发现了一种与霍克斯基因相互作用的特异性增强剂,
结论:
- 基因组重组和调节变异在表型特征的进化中起着重要作用.
- 平面细胞极性通路和霍克斯基因调节对于巴托类形态的发展至关重要.
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