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在从熊到人类的哺乳动物物种中保留了与不运动相关的血栓保护

Manuela Thienel1,2, Johannes B Müller-Reif3,4, Zhe Zhang1

  • 1Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany.

Science (New York, N.Y.)
|April 13, 2023
PubMed
概括

冬眠中的熊和脊髓损伤患者受到静脉血栓塞栓症 (VTE) 的保护. 血小板中减少的热冲击蛋白47 (HSP47) 提供了这种血栓保护的跨物种机制.

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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