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一个体质认知行动网络与运动皮层中的效应区域交替
Evan M Gordon1, Roselyne J Chauvin2, Andrew N Van2,3
1Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA. egordon@wustl.edu.
Nature
|April 19, 2023
概括
运动皮质 (M1) 不是一个连续的同质体,而是具有不同的行动规划区域,称为体认性行动网络 (SCAN),以及用于精细运动控制的效应器特定区域.
科学领域:
- 神经科学
- 认知神经科学
- 神经成像
背景情况:
- 运动皮层 (M1) 传统上被视为用于运动控制的连续体内图 (homunculus).
- 新出现的证据表明复杂行动的功能区和地图, 挑战了简单的同胞模型.
- 在整合行动计划与生理控制和唤醒方面M1的作用仍然不完全理解.
研究的目的:
- 使用高分辨率fMRI研究人类运动皮质 (M1) 的详细功能组织.
- 识别和描述M1内的不同功能区域,超出了经典的体位表征.
- 探索这些地区的连接,结构和功能以及它们与行动规划和控制的关系.
主要方法:
- 在多个大数据集中对人类参与者使用精确的功能磁共振成像 (fMRI).
- 进行了跨物种 () 和发育 (儿科) 的fMRI研究,以检查进化和发育方面的情况.
- 使用一系列的运动和动作fMRI任务,
主要成果:
- 发现M1被不同的效应器区域中断,与效应器特定的 (脚,手,嘴) 区域交替.
- 这些相互影响的区域显示皮质厚度下降,彼此具有强大的功能连接性,并与皮带细胞网络 (CON) 连接.
- 确定这些相互影响的区域作为拟议体认知行动网络 (SCAN) 的一部分,参与行动计划和全身运动,缺乏具体的运动代表性.
结论:
- 运动皮层 (M1) 包含两个相互交织的系统:用于精细运动的效应器特定区域和用于综合行动规划的SCAN.
- SCAN整合了目标,生理和身体运动,挑战了传统的M1仅仅是一个体质地图.
- 证据表明这种SCAN系统的跨物种和发育前体,强调其在运动控制中的基本作用.
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