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Updated: Aug 2, 2025

A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers
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致癌CDK13突变阻碍了核RNA监测

Megan L Insco1,2, Brian J Abraham3, Sara J Dubbury4,5

  • 1Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.

Science (New York, N.Y.)
|April 20, 2023
PubMed
概括

破坏核RNA监测会导致癌症. 循环蛋白依赖性酶13 (CDK13) 突变会损害RNA降解,通过稳定异常转录加速黑色素瘤.

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