在基分子容器中进行三倍三倍的消灭升级
Hongliang Chen1,2,3, Indranil Roy2, Michele S Myong2
1Department of Chemistry, Stoddart Institute of Molecular Science, Zhejiang University, Hangzhou 310027, China.
Journal of the American Chemical Society
|April 25, 2023
概括
这项研究展示了一种新的宿主-客户策略,用于使用类似子容器的分子光子上转换. 这种方法可以在单个超级分子中实现高效的三倍灭绝转化,用于潜在的生物成像应用.
科学领域:
- 光物理与超分子化学
- 有机和材料科学
背景情况:
- 基于三次灭绝的光子上转换 (TTA-UC) 将低能光转换为高能光子.
- 有效的TTA-UC依赖于精确控制敏感剂和消灭剂分子之间的分子间距离和方向.
- 现有的方法面临样本度,聚合和透深度的挑战.
研究的目的:
- 为控制分子内TTA-UC制定宿主-客人策略.
- 设计一个分子容器, 精确地定位传感器和发射器,
- 在单个超分子实体内证明TTA-UC.
主要方法:
- 设计和合成一个类似子的分子容器,其中包含氨酸敏感剂.
- 在容器腔内封装烯发射器,形成宿主:客人复合体.
- 使用NMR光谱学,质谱学,同热度定位热量计 (ITC) 和DFT计算进行表征.
- 用低能光子激发,观察TTA-UC发射.
主要成果:
- 一个宿主:客人复合体,容器与烯的比率为1:2成功形成.
- 量身定制的腔体大小 (9.6-10.4 Å) 确保了染色体之间的最佳[π··π]堆叠距离 (3.2-3.5 Å).
- 在用低能光激发时,达到TTA-UC,产生470nm的蓝色辐射.
- 在单个超分子内测定分子内TTA-UC的概念验证.
结论:
- 宿主-客人策略可以在一个明确的超分子系统中实现高效的TTA-UC.
- 这种方法克服了传统的TTA-UC方法的局限性,例如聚合和度依赖.
- 这些发现为TTA-UC应用开辟了新的途径,特别是在生物成像中.
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