与宿主病原体防御不同的组织损伤感知和修复途径
Siqi Liu1, Yun Ha Hur1, Xin Cai2
1Robin Chemers Neustein Laboratory of Mammalian Development and Cell Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Cell
|April 25, 2023
概括
干白素-24 (IL-24) 主要是在组织损伤后由上皮细胞产生,而不是感染. IL-24对于伤口愈合至关重要,促进组织再生和修复.
科学领域:
- 细胞生物学
- 免疫学
- 复原医学
背景情况:
- 病原体感染和组织损伤会破坏身体的内在平衡 (平衡).
- 遗传免疫能检测到微生物并释放信号分子来对抗感染.
- 大多数细胞因子是由病原体诱导的,但IL-24在组织修复中的作用是不同的.
研究的目的:
- 为了研究Interleukin-24 (IL-24) 在受伤后的组织修复中的作用.
- 确定IL-24诱导的细胞源和调节机制.
- 阐明参与IL-24介导组织再生的信号通路.
主要方法:
- 在小鼠组织损伤后对上皮原体的IL-24诱导进行了研究.
- 在小鼠中利用IL-24基因切除 (Il24敲除) 来评估它的功能.
- 研究了宫外IL-24诱导对平静表皮的作用.
- 分析了包括IL24受体/STAT3和HIF1α在内的信号通路.
主要成果:
- 在组织受伤后,IL-24主要由屏障上皮原体诱导,独立于微生物组或适应性免疫.
- 在小鼠中,IL24缺乏会影响表皮增殖,再表皮化和皮肤伤口愈合.
- 在健康的皮肤中,宫外IL-24诱导引发了广泛的组织修复反应.
- IL-24信号依赖于上皮IL24受体/STAT3和低氧诱导的HIF1α.
结论:
- 皮质干细胞利用IL-24进行组织修复以应对损伤信号.
- IL-24 作为关键的介质,将损伤感应与组织再生联系起来.
- 这与天生的免疫在传染病原体的感知作用形成鲜明对比.
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