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在一生中心脏热素轨迹的性别差异

Marie de Bakker¹, Atul Anand², Martin Shipley³

¹Department of Cardiology, Erasmus MC Cardiovascular Institute, University Medical Center Rotterdam, the Netherlands (M.d.B., I.K., E.B.).

|April 28, 2023

概括

女性心脏中热素水平低于男性,但随着年龄的增长而增加. 对心脏热素轨迹的性别特定分析对于两性心血管风险预测至关重要.

科学领域:

心脏病学
生物标志物
人口健康

背景情况:

妇女的心脏度通常低于男性.
了解随着时间的推移,心脏素的性别特异性变化对于心血管健康至关重要.
需要根据性别研究心脏热素轨迹与心血管风险因素之间的关系.

研究的目的:

检查与年龄和风险因素相关的心脏素的性别差异.
确定心脏热素轨迹是否对女性和男性的心血管结果有不同的预测.
评估对一般人群心血管风险分层的连续心脏素测试的有用性.

主要方法:

使用线性混合效应模型分析怀特霍尔II队列15年内特定性别的心脏素I轨迹.
使用多种状态的关节模型来评估心脏素轨迹与心血管事件 (心肌梗塞,中风,心血管死亡) 之间的关联.
评估了性别,年龄,BMI,糖尿病和心脏热素水平之间的相互作用,以影响心血管结果.

主要成果:

妇女的心脏度持续低于男性,但随着年龄的增长,女性的心脏度增加 (P< 0. 001).
对于心脏特罗因相关性,观察到显著的性别-BMI和性别-糖尿病相互作用.
心脏热素度与两性心血管结果相关;心脏热素增加的斜率与女性的结果有显著的相关性.

结论:

在一般人群中,心脏热素轨迹呈现出显著的性别差异.
这些性别特异性轨迹与不同的心血管风险因素和结果有关.
通过连续性心脏热素检测来准确预测心血管风险,以性别为特征的方法至关重要.

关键词:

心血管疾病人口健康风险评估性别问题其他:

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