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Updated: Jul 31, 2025

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
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基于结构的型选择性抑制剂的发现

Isha Singh1, Anubha Seth2, Christian B Billesbølle1

  • 1Department of Pharmaceutical Chemistry, University of California, San Francisco, 1700 4th St., Byers Hall Suite 508D, San Francisco, CA 94143, USA.

Cell
|May 3, 2023
PubMed
概括

开发了针对内向开放状态的新型血清素转运体 (SERT) 抑制剂,在小鼠中表现出强烈的抗抑郁和抗焦虑作用. 这些新型化合物还可以逆转吗啡戒断症状,

关键词:
抑郁症停靠功能选择性血清素运输体超大型图书馆

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